Oral Squamous Cell Carcinoma of the Tongue in the Setting of Electronic Cigarette Use
DOI:
https://doi.org/10.52845/JORR/2023/4.3.2Abstract
Abstract: The understanding of short and long-term health impacts of electronic cigarette use are limited by the paucity of longitudinal data and a wide heterogeneity amongst products. Recent in-vitro and in-vivo studies have demonstrated the carcinogenic potential of several compounds found in electronic cigarette vapers. We present a case of a 17-year-old male presented with a biopsy proven HPV negative squamous cell carcinoma of the tongue. The only pertinent history was a frequent daily use of an electronic nicotine delivery system (ENDS), or electronic cigarette. The patient underwent a partial glossectomy and ipsilateral left modified radical neck dissection. Though sufficient literature is unavailable to link ENDS to oral cancer, contemporary evidence highlights a multitude of carcinogenic properties. With rising ENDS usage amongst youth populations, both physicians and patients need to be aware of the potential risks.
References
Cullen KA, Gentzke AS, Sawdey MD, et al. e-Cigarette Use Among Youth in the United States, 2019. JAMA. 2019;322(21):2095–2103.
Chapman S, Bareham D, Maziak W. The Gateway Effect of E-cigarettes: Reflections on Main Criticisms. Nicotine Tob Res. 2019;21(5):695-698. doi:10.1093/ntr/nty067
Dai H, Leventhal AM. Prevalence of e-Cigarette Use Among Adults in the United States, 2014-2018. JAMA. 2019;322(18):1824–1827.
Villarroel M, Cha A, Vahratian A. (2018). Electronic Cigarette Use Among U.S. Adults, 2018 Key findings Data from the National Health Interview Survey. https://www.cdc.gov/nchs/products/index.htm.
Cullen KA, Ambrose BK, Gentzke AS, Apelberg BJ, Jamal A, King BA. Notes from the Field: Use of Electronic Cigarettes and Any Tobacco Product Among Middle and High School Students - United States, 2011-2018. MMWR Morb Mortal Wkly Rep. 2018;67(46):1276‐1277. Published 2018 Nov 16.
Gentzke AS, Creamer M, Cullen KA, et al. Vital Signs: Tobacco Product Use Among Middle and High School Students—United States, 2011–2018. Morbidity and Mortality Weekly Report 2019;68:157–164.
Wang, T. W., Neff, L. J., Park-Lee, E., Ren, ; Chunfeng, Cullen, K. A., & King, B. A. (n.d.). Morbidity and Mortality Weekly Report E-cigarette Use Among Middle and High School Students-United States, 2020. https://doi.org/10.1001/jama.2019.18387
Sultan AS, Jessri M, Farah CS. Electronic nicotine delivery systems: Oral health implications and oral cancer risk [published online ahead of print, 2018 Dec 3]. J Oral Pathol Med. 2018;10.1111/jop.12810.
Goniewicz ML, Knysak J, Gawron M, et al. Levels of selected carcinogens and toxicants in vapour from electronic cigarettes. Tob Control. 2014;23(2):133–139.
Ween MP, Whittall JJ, Hamon R, Reynolds PN, Hodge SJ. Phagocytosis and Inflammation: Exploring the effects of the components of E-cigarette vapor on macrophages. Physiol Rep. 2017;5(16):e13370.
Yu V, Rahimy M, Korrapati A, et al. Electronic cigarettes induce DNA strand breaks and cell death independently of nicotine in cell lines. Oral Oncol. 2016;52:58–65.
Tommasi S, Caliri AW, Caceres A, et al. Deregulation of Biologically Significant Genes and Associated Molecular Pathways in the Oral Epithelium of Electronic Cigarette Users. Int J Mol Sci. 2019;20(3):738. Published 2019 Feb 10.
